Dr. Dennis Gross SkincareserumTreat step

Dr. Dennis Gross Skincare DermInfusions Fill + Repair Serum with Hyaluronic Acid

This serum aims to mimic the effects of injectables by plumping and firming the skin. It uses multiple forms of hyaluronic acid to hydrate at different levels, and peptides to boost collagen and volume. It also includes barrier-supporting ingredients like niacinamide and ectoin.

Sephora price

$78.00

Price matters most when you are trying to learn whether this lane belongs in your routine without turning the test into a luxury gamble.

Sephora reviews

4.3 / 5

About 451 reviews on the current Sephora source, so there is real volume behind the reputation.

Shoppers keep mentioning

Anti-AgingVeganDrynessLoss of firmnessPlumping4 Weights of Hyaluronic Acid: Penetrates the skin at different levels to create a 3D-plumped effect and fill the look of fine lines.4 Peptide Proteins: Visibly adds volume and firms skin.Niacinamide and Ectoin: Reduces redness and support the skin barrier.Fine Lines and WrinklesDrynessand Loss of Firmness and Elasticity

These are the shopper themes that keep showing up around this listing and shape why people open it in the first place.

Glass take

4.3 / 5 overall fit

A multi-tasking serum that targets multiple signs of aging, with a focus on plumping and firming. It's a good option for those looking for an alternative to injectables.

Dr. Dennis Gross Skincare DermInfusions Fill + Repair Serum with Hyaluronic Acid

Sephora snapshot refreshed April 23, 2026

Price, rating, review count, and source status come from Sephora. Glass adds the routine fit, overlap risk, and what to compare next.

View Sephora

What Sephora says

What this product is supposed to do

An alternative to injectable filler that visibly fills lines, plumps, and firms skin while restoring skin’s moisture barrier function for a more youthful complexion.

NormalDryCombinationand OilyFine Lines and WrinklesDrynessand Loss of Firmness and Elasticity

For morning and evening use.

Use two to three pumps, massage into full face, targeting wrinkles.

For optimal results, apply after your Dr. Dennis Gross Skincare peel and follow with a moisturizer if needed.

What Glass adds

What actually matters before you buy it

This serum is a strong contender for those concerned with fine lines, wrinkles, and loss of firmness. The combination of multiple hyaluronic acid weights and peptides offers a comprehensive approach to plumping and smoothing. It's particularly useful for dry or dehydrated skin, and for those who want to support their skin barrier.

Plumping and hydration

Many users report a noticeable plumping effect and improved hydration after consistent use, attributing it to the various hyaluronic acid forms.

Firming and line reduction

The peptide complex is praised for its ability to visibly reduce the appearance of fine lines and improve skin firmness over time.

Best for

When this is a smart buy

  • Mature skin
  • Dry or dehydrated skin
  • Loss of firmness
  • Fine lines and wrinkles

Skip if

When this is the wrong lane

  • You have very sensitive skin and are not accustomed to multiple acids
  • You are looking for a serum solely focused on acne or hyperpigmentation

Routine fit

How to integrate this serum

Apply this serum after your Dr. Dennis Gross Skincare peel, or after cleansing if you are not using a peel. Follow with a moisturizer to lock in hydration. It can be used both in the morning and evening.

Why it works

Where it earns the slot and where it does not

The useful question is not whether this product is good in a vacuum. It is whether it makes your routine easier to run or just adds one more bottle with a familiar ingredient on it.

What it actually does well

  • Addresses multiple signs of aging
  • Plumps and firms skin
  • Supports skin barrier
  • Contains multiple forms of hyaluronic acid

Where it starts to feel redundant

  • High price point
  • Potential for irritation if skin is not accustomed to acids

Routine fit

Where it belongs in the stack

Morning or night

This serum is suitable for both morning and evening use. Applying it after cleansing and before moisturizer is recommended.

Glass rating

How this formula scores in real life

4.3/ 5 overall

A multi-tasking serum that targets multiple signs of aging, with a focus on plumping and firming. It's a good option for those looking for an alternative to injectables.

Routine fit

4.5 / 5

Works well after peels and before moisturizer. Can be used morning and night.

Ingredient quality

4.2 / 5

A complex blend of hyaluronic acids, peptides, and barrier-supporting ingredients.

Full ingredient breakdown

Every ingredient, what it does, and whether I care

Solvent

Water/Aqua/Eau

Badness

0.0 / 10

The base of the formulation.

Usually helps with

All skin types

Watch for

None

Humectant

Glycerin

Badness

0.0 / 10

Draws moisture to the skin, keeping it hydrated and soft.

Usually helps with

Dryness, hydration

Watch for

None

Active

Niacinamide

Badness

2.0 / 10

Helps to reduce redness, support the skin barrier, and improve skin texture. Can also help with oil control.

Usually helps with

Redness, barrier support, texture

Watch for

Can cause flushing or irritation in some individuals, especially at higher concentrations.

Humectant

Butylene Glycol

Badness

0.0 / 10

A common solvent and humectant that helps ingredients penetrate the skin.

Usually helps with

Hydration, penetration

Watch for

None

Soothing Agent

Ectoin

Badness

1.0 / 10

A natural compound that helps protect skin cells from environmental stressors and supports the skin barrier.

Usually helps with

Barrier support, redness reduction

Watch for

None

Humectant

Sodium Hyaluronate

Badness

0.0 / 10

A salt form of hyaluronic acid that attracts and holds moisture in the skin.

Usually helps with

Hydration, plumping

Watch for

None

Humectant

Hydrolyzed Sodium Hyaluronate

Badness

0.0 / 10

A smaller molecule form of hyaluronic acid that can penetrate deeper into the skin for enhanced hydration.

Usually helps with

Deep hydration, plumping

Watch for

None

Humectant

Sodium Acetylated Hyaluronate

Badness

0.0 / 10

A modified form of hyaluronic acid that has improved skin penetration and retention.

Usually helps with

Long-lasting hydration, plumping

Watch for

None

Humectant

Sodium Hyaluronate Crosspolymer

Badness

0.0 / 10

A cross-linked form of hyaluronic acid that forms a film on the skin's surface to prevent moisture loss.

Usually helps with

Surface hydration, barrier support

Watch for

None

Peptide

Acetyl Hexapeptide-8

Badness

1.0 / 10

A peptide that mimics the effects of Botox, helping to relax facial muscles and reduce the appearance of expression lines.

Usually helps with

Expression lines, anti-aging

Watch for

None

Peptide

Palmitoyl Tripeptide-1

Badness

1.0 / 10

A peptide that stimulates collagen production, helping to improve skin firmness and reduce wrinkles.

Usually helps with

Firmness, wrinkles

Watch for

None

Peptide

Palmitoyl Tetrapeptide-7

Badness

1.0 / 10

A peptide that helps to reduce inflammation and support skin repair, contributing to a smoother complexion.

Usually helps with

Skin repair, anti-aging

Watch for

None

Peptide

Oligopeptide-2

Badness

1.0 / 10

A signaling peptide that promotes cell regeneration and helps to improve skin elasticity.

Usually helps with

Elasticity, anti-aging

Watch for

None

Humectant

Saccharide Isomerate

Badness

0.0 / 10

A plant-derived ingredient that binds to skin cells to provide long-lasting hydration.

Usually helps with

Hydration, dry skin

Watch for

None

Antioxidant

Camellia Sinensis (Green Tea) Leaf Extract

Badness

1.0 / 10

Rich in antioxidants, it helps protect the skin from environmental damage and has anti-inflammatory properties.

Usually helps with

Antioxidant protection, soothing

Watch for

None

Antioxidant

Camellia Sinensis (White Tea) Leaf Extract

Badness

1.0 / 10

Similar to green tea, it provides antioxidant benefits and helps to calm the skin.

Usually helps with

Antioxidant protection, soothing

Watch for

None

Soothing Agent

Centella Asiatica Extract

Badness

1.0 / 10

Known for its wound-healing and anti-inflammatory properties, it helps to soothe and repair the skin.

Usually helps with

Soothing, repair, redness

Watch for

None

Antioxidant

Vitis Vinifera (Grape) Seed Extract

Badness

1.0 / 10

A potent antioxidant that helps protect the skin from free radical damage.

Usually helps with

Antioxidant protection

Watch for

None

Soothing Agent

Sodium Carboxymethyl Beta-Glucan

Badness

1.0 / 10

A derivative of beta-glucan that helps to soothe and condition the skin, while also supporting barrier function.

Usually helps with

Soothing, barrier support

Watch for

None

Antioxidant

Bakuchiol

Badness

2.0 / 10

A plant-based ingredient often considered a natural alternative to retinol, it helps to improve skin texture and reduce the appearance of fine lines.

Usually helps with

Anti-aging, texture improvement

Watch for

Can cause mild irritation or peeling in some individuals, similar to retinol.

Antioxidant

Inonotus Obliquus (Mushroom) Extract

Badness

1.0 / 10

Contains antioxidants that help protect the skin from environmental damage.

Usually helps with

Antioxidant protection

Watch for

None

Antioxidant

Tetrahydrocurcumin

Badness

2.0 / 10

A derivative of curcumin with antioxidant and brightening properties.

Usually helps with

Brightening, antioxidant protection

Watch for

Can potentially cause staining due to its color.

Skin-Replenishing

Ceramide NP

Badness

1.0 / 10

A type of lipid that is a natural component of the skin barrier, helping to restore and maintain hydration.

Usually helps with

Barrier repair, hydration

Watch for

None

Skin-Replenishing

Ceramide AP

Badness

1.0 / 10

Another type of ceramide that supports the skin barrier and helps prevent moisture loss.

Usually helps with

Barrier repair, hydration

Watch for

None

Skin-Replenishing

Ceramide EOP

Badness

1.0 / 10

A key ceramide that helps to strengthen the skin barrier and improve overall skin health.

Usually helps with

Barrier repair, skin health

Watch for

None

Emollient

Phospholipids

Badness

1.0 / 10

Help to form the skin's barrier, improving hydration and suppleness.

Usually helps with

Barrier function, hydration

Watch for

None

Skin-Replenishing

Sphingolipids

Badness

1.0 / 10

Lipids that are crucial components of the skin barrier, helping to maintain its integrity and function.

Usually helps with

Barrier function, skin health

Watch for

None

Skin-Replenishing

Phytosphingosine

Badness

1.0 / 10

A lipid that plays a role in skin barrier function and has anti-inflammatory properties.

Usually helps with

Barrier function, anti-inflammatory

Watch for

None

Soothing Agent

Colloidal Oatmeal

Badness

1.0 / 10

Known for its ability to soothe irritated and itchy skin.

Usually helps with

Soothing, irritation

Watch for

None

Soothing Agent

Bisabolol

Badness

1.0 / 10

A component of chamomile, it has anti-inflammatory and soothing properties.

Usually helps with

Soothing, redness reduction

Watch for

None

Antioxidant

Superoxide Dismutase

Badness

2.0 / 10

An enzyme that helps protect cells from damage caused by free radicals.

Usually helps with

Antioxidant protection

Watch for

None

Antioxidant

Terminalia Ferdinandiana (Kakadu Plum) Fruit Extract

Badness

1.0 / 10

Extremely rich in Vitamin C, providing potent antioxidant benefits.

Usually helps with

Antioxidant protection, brightening

Watch for

None

Humectant

Sodium PCA

Badness

0.0 / 10

A component of the skin's natural moisturizing factor, it helps to attract and retain moisture.

Usually helps with

Hydration

Watch for

None

Antioxidant

Glutathione

Badness

3.0 / 10

A powerful antioxidant that can help brighten the skin and protect against environmental damage.

Usually helps with

Brightening, antioxidant protection

Watch for

Can be unstable in formulations; effectiveness may vary.

Emollient

Squalane

Badness

0.0 / 10

A lightweight, non-comedogenic oil that mimics the skin's natural sebum, providing hydration and improving suppleness.

Usually helps with

Hydration, all skin types

Watch for

None

Antioxidant

Caffeine

Badness

1.0 / 10

Can help to temporarily reduce puffiness and redness.

Usually helps with

Puffiness reduction, antioxidant

Watch for

None

Humectant

Panthenol

Badness

0.0 / 10

A form of Vitamin B5 that attracts and holds moisture, improving skin hydration and softness.

Usually helps with

Hydration, soothing

Watch for

None

Emollient

Butyrospermum Parkii (Shea) Butter

Badness

1.0 / 10

A rich moisturizer that helps to soften and smooth the skin.

Usually helps with

Dryness, softening

Watch for

Can be heavy for very oily skin types.

Soothing Agent

Aloe Barbadensis Leaf Juice

Badness

0.0 / 10

Known for its soothing, hydrating, and anti-inflammatory properties.

Usually helps with

Soothing, hydration, irritation

Watch for

None

Soothing Agent

Arnica Montana Flower Extract

Badness

1.0 / 10

Used to help reduce swelling and bruising, and calm the skin.

Usually helps with

Soothing, reducing inflammation

Watch for

None

Skin-Replenishing

Acetyl Glutamine

Badness

1.0 / 10

An amino acid derivative that helps to support skin hydration and barrier function.

Usually helps with

Hydration, barrier support

Watch for

None

Skin-Replenishing

Bifida Ferment Lysate

Badness

2.0 / 10

A probiotic ingredient that helps to strengthen the skin barrier and improve skin's resilience.

Usually helps with

Barrier support, resilience

Watch for

None

Soothing Agent

Chamomilla Recutita (Matricaria) Flower Extract

Badness

1.0 / 10

Has anti-inflammatory and calming properties, beneficial for sensitive or irritated skin.

Usually helps with

Soothing, calming

Watch for

None

Antioxidant

Withania Somnifera (Ashwagandha) Root Extract

Badness

1.0 / 10

An adaptogen with antioxidant properties that can help protect the skin from stress.

Usually helps with

Antioxidant protection, stress defense

Watch for

None

Exfoliant

Glycolic Acid

Badness

4.0 / 10

An AHA that exfoliates the skin, helping to improve texture, tone, and reduce the appearance of fine lines. Can be irritating.

Usually helps with

Exfoliation, texture, tone

Watch for

Can cause redness, peeling, and increased sun sensitivity. Start slowly.

Exfoliant

Mandelic Acid

Badness

3.0 / 10

A larger molecule AHA that exfoliates more gently than glycolic acid, making it suitable for sensitive skin.

Usually helps with

Gentle exfoliation, acne-prone skin

Watch for

Can still cause irritation and sun sensitivity.

Exfoliant

Lactobionic Acid

Badness

2.0 / 10

A PHA that exfoliates gently and also has humectant properties, helping to hydrate the skin.

Usually helps with

Gentle exfoliation, hydration

Watch for

None

Preservative

Ethylhexylglycerin

Badness

1.0 / 10

A preservative that also has skin-conditioning properties.

Usually helps with

Preservation, skin conditioning

Watch for

None

Surfactant

Coco-Glucoside

Badness

0.0 / 10

A mild, plant-derived surfactant used for cleansing.

Usually helps with

Cleansing

Watch for

None

Surfactant

Lauryl Glucoside

Badness

0.0 / 10

A mild, plant-derived surfactant used for cleansing.

Usually helps with

Cleansing

Watch for

None

Surfactant

Decyl Glucoside

Badness

0.0 / 10

A mild, plant-derived surfactant used for cleansing.

Usually helps with

Cleansing

Watch for

None

Emulsifier

Polyglyceryl-10 Laurate

Badness

0.0 / 10

A gentle emulsifier that helps to blend oil and water ingredients.

Usually helps with

Formulation stability

Watch for

None

Emollient

Diheptyl Succinate

Badness

1.0 / 10

A plant-derived emollient that helps to soften and smooth the skin.

Usually helps with

Softening, smoothing

Watch for

None

Emollient

Dimethicone

Badness

1.0 / 10

A silicone that forms a protective barrier on the skin, helping to reduce moisture loss and provide a smooth feel.

Usually helps with

Occlusion, smoothing

Watch for

Can feel heavy on oily skin; some prefer to avoid silicones.

Humectant

Pentylene Glycol

Badness

0.0 / 10

A humectant that helps to hydrate the skin and improve the texture of formulations.

Usually helps with

Hydration, texture

Watch for

None

Emulsifier

Sodium Lauroyl Lactylate

Badness

1.0 / 10

A gentle emulsifier derived from lactic acid and lauric acid.

Usually helps with

Formulation stability

Watch for

None

Film Former

PVM/MA Decadiene Crosspolymer

Badness

1.0 / 10

Helps to form a film on the skin, providing a smooth feel and potentially improving the wear of other products.

Usually helps with

Texture, film-forming

Watch for

None

Film Former

VP/VA Copolymer

Badness

1.0 / 10

Forms a flexible film on the skin, providing hold and texture.

Usually helps with

Texture, film-forming

Watch for

None

Thickener

Xanthan Gum

Badness

0.0 / 10

A common thickening agent that improves the texture and stability of formulations.

Usually helps with

Texture, stability

Watch for

None

pH Adjuster

Potassium Hydroxide

Badness

0.0 / 10

Used to adjust the pH of the formulation.

Usually helps with

Formulation stability

Watch for

None

Emulsifier

Polysorbate 20

Badness

1.0 / 10

A gentle emulsifier used to help dissolve oils in water-based formulas.

Usually helps with

Formulation stability

Watch for

None

Emollient

Dimethicone Crosspolymer

Badness

1.0 / 10

A silicone that provides a smooth, silky feel and can help to mattify the skin.

Usually helps with

Texture, mattifying

Watch for

Can feel heavy on oily skin; some prefer to avoid silicones.

Thickener

Carbomer

Badness

0.0 / 10

A thickening agent used to create gel-like textures.

Usually helps with

Texture, stability

Watch for

None

Emollient

Cholesterol

Badness

1.0 / 10

A lipid that helps to reinforce the skin barrier and improve hydration.

Usually helps with

Barrier support, hydration

Watch for

None

Emollient

Capryloyl Glycerin/Sebacic Acid Copolymer

Badness

1.0 / 10

A conditioning agent that helps to soften and smooth the skin.

Usually helps with

Softening, smoothing

Watch for

None

Preservative

Leuconostoc/Radish Root Ferment Filtrate

Badness

1.0 / 10

A natural preservative derived from fermented radish root.

Usually helps with

Preservation

Watch for

None

pH Adjuster

Sodium Citrate

Badness

0.0 / 10

Used to adjust the pH of the formulation.

Usually helps with

Formulation stability

Watch for

None

pH Adjuster

Citric Acid

Badness

0.0 / 10

Used to adjust the pH of the formulation.

Usually helps with

Formulation stability

Watch for

None

pH Adjuster

Sodium Metasilicate

Badness

0.0 / 10

Used to adjust the pH of the formulation.

Usually helps with

Formulation stability

Watch for

None

Exfoliant

Gluconolactone

Badness

2.0 / 10

A PHA that gently exfoliates and hydrates the skin.

Usually helps with

Gentle exfoliation, hydration

Watch for

None

Chelating Agent

Tetrasodium Glutamate Diacetate

Badness

0.0 / 10

Helps to stabilize the formulation by binding to metal ions.

Usually helps with

Formulation stability

Watch for

None

Emollient

Caprylic/Capric Triglyceride

Badness

0.0 / 10

A lightweight emollient derived from coconut oil and glycerin that helps to replenish the skin.

Usually helps with

Emollience, hydration

Watch for

None

Fragrance

Jasminum Officinale (Jasmine) Flower/Leaf Extract

Badness

2.0 / 10

Adds a pleasant scent to the product. Can be a potential irritant for sensitive skin.

Usually helps with

Fragrance

Watch for

Potential for irritation or allergic reaction in sensitive individuals.

Antioxidant

Vitis Vinifera (Grape) Fruit Extract

Badness

1.0 / 10

Contains antioxidants that help protect the skin from damage.

Usually helps with

Antioxidant protection

Watch for

None

Fragrance

Eugenia Caryophyllus (Clove) Flower Extract

Badness

3.0 / 10

Adds a strong scent. Can be irritating for some skin types.

Usually helps with

Fragrance

Watch for

Potential for irritation or allergic reaction, especially for sensitive skin.

Fragrance

Lavandula Angustifolia (Lavender) Flower/Leaf/Stem Extract

Badness

2.0 / 10

Provides a calming scent. Can be a potential irritant for sensitive skin.

Usually helps with

Fragrance

Watch for

Potential for irritation or allergic reaction in sensitive individuals.

Fragrance

Raspberry Ketone

Badness

2.0 / 10

Adds a fruity scent. Can be a potential irritant for sensitive skin.

Usually helps with

Fragrance

Watch for

Potential for irritation or allergic reaction in sensitive individuals.

Preservative

Phenoxyethanol

Badness

2.0 / 10

A common preservative. Can cause irritation in some individuals.

Usually helps with

Preservation

Watch for

Can cause skin irritation or allergic reactions in sensitive individuals.

Preservative

Potassium Sorbate

Badness

1.0 / 10

A common preservative used to prevent microbial growth.

Usually helps with

Preservation

Watch for

None

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FAQ

The fast answers people actually need

Is this serum a good alternative to injectables?

This serum is designed to mimic the effects of injectables by visibly filling lines, plumping, and firming the skin. While it won't provide the same dramatic results as fillers, it can offer a significant improvement in the appearance of aging skin.

Can I use this serum if I have sensitive skin?

This serum contains AHAs and PHAs, which can be irritating for sensitive skin. It's recommended to start slowly, perhaps using it only a few times a week, and to patch test first. If you have very sensitive skin, you may want to consider a gentler alternative.

How does the hyaluronic acid in this serum work?

The serum contains four different weights of hyaluronic acid. This allows it to penetrate the skin at various levels, providing hydration and plumping effects both on the surface and deeper within the skin.